Any opioid-based painkiller can lead to addiction. Opioid derivatives – or narcotics – are commonly used in prescription painkillers. Morphine, oxymorphone (Opana ER), oxycodone (Oxycontin, Oxecta), hydrocodone (Zohydro ER), codeine, methadone, and fentanyl are examples of the potent opiate medications at the center of the U.S. addiction epidemic.